Engineering the Live-Attenuated Polio Vaccine to Prevent Reversion to Virulence

African Horse Sickness Caused by Genome Reassortment and Reversion to Virulence of Live, Attenuated Vaccine Viruses, South Africa, 2004–2014

African horse sickness (AHS) is a hemorrhagic viral fever of horses. It is the only equine disease for which the World Organization for Animal Health has introduced specific guidelines for member countries seeking official recognition of disease-free status. Since 1997, South Africa has maintained an AHS controlled area; however, sporadic outbreaks of AHS have occurred in this area. We compared...

Reversion to the Neurovilurent Genome Sequence of Polio Vaccine Virus Isolated from Community-Acquired Meningitis

Neurologic complication associated with the use of live attenuated oral poliomyelitis vaccine is uncommon, but vaccine-associated paralytic poliomyelitis in recipients or contacts has sometimes been reported. We report here a community-acquired aseptic meningitis case and the genetic investigation of the isolated poliovirus type 2. The results of the genetic analysis indicate that the mechanism...

Development of an Attenuated Live Virus Vaccine against Sheep Pox

Live Oral Poliovirus Vaccine after DPT Polio Vaccine.

In the editorial note on Controlled Drugs which I contributed to the issue of September 9 (Canad. M. A. J., 85: 661, 1961), I find that I have overstated the case for written prescriptions for the amphetamines and the barbiturates. Pharmacists may dispense Controlled Drugs on the strength of a prescription given verbally by a physician as well as by a prescription in writing. The pharmacist mus...

Experimental study of a further attenuated live measles vaccine of the Sugiyama strain in Iran